Author/Authors :
Pizzichini، G. نويسنده , , R Pagani، نويسنده , , A Tabucchi، نويسنده , , F Carlucci، نويسنده , , R Leoncini، نويسنده , , D Vannoni، نويسنده , , E Consolmagno، نويسنده , , E Marinello، نويسنده , , E Dispensa، نويسنده ,
Abstract :
Purine nucleotides were studied in human peripheral blood lymphocytes from normal subjects and patients with chronic B-cell lymphocytic leukemia (B-CLL). Nucleotide content was determined by high performance liquid chromatography (HPLC). The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a lymphocytic suspension. Results indicate a substantially reduced rate of purine nucleotide metabolism
