The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers

Aim To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers. Methods Through the analysis of DCsʹ surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs. Results OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs. Conclusion OK-432 can induce DCsʹ maturation and can thus promote CIKsʹ functions.