Effect of intracoronary saline infusion on dissection during excimer laser coronary angioplasty: randomized trial

Objectives. We sought to evaluate whether intracoronary saline infusion during excimer laser coronary angioplasty decreases the incidence of significant laser-induced coronary artery dissections. Background. Despite procedural success rates >90%, coronary artery dissections occur in 17% to 27% of excimer laser coronary angioplasty procedures. Excimer laser irradiation of blood results in vapor bubble formation and acoustomechanical traum to the vessel wall. Saline infusion into coronary artery may minimize blood irradiation and consequent arterial wall damage. Methods. In this prospective, randomized, controlled study, consecutive patients undergoing excimer laser coronary angioplasty were randomly assigned to conventional laser irradiation in blood medium or to laser irradiation with blood displacement by intracoronary saline infusion. In the patients randomized to intracoronary saline infusion, prewarmed normal saline was injected through the coronary artery guide catheter at rate of 1 to 2 ml/s using power injector. The incidence and severity of dissection after excimer laser ablation were evaluated in core laboratory by angiographers with no knowledge of treatment assignment. The severity of coronary artery dissection was rated on an ordinal scale of 1 to 5. Dissections of grade 2 or higher were considered significant. Results. The mean (±SE) dissection grade after laser angioplasty in patients treated with intracoronary saline infusion was 0.43 ± 0.13 compared with 0.91 ± 0.26 in patients undergoing laser angioplasty in blood medium. The incidence of significant dissection was 7% in saline-treated patients compared with 24% in conventionally treated patients (p < 0.05). No significant complications were associated with saline infusion. Conclusions. Intracoronary saline infusion should be incorporated into all excimer laser coronary angioplasty procedures.