Optimal right ventricular pacing site in chronically implanted patients: prospective randomized crossover comparison of apical and outflow tract pacing

Objectives To evaluate the long-term functional and hemodynamic effects of right ventricular outflow tract (RVOT) pacing by comparison with right ventricular apical (RVA) pacing. Background Acute studies have suggested that RVOT pacing could significantly improve cardiac performance in comparison with RV pacing but no dat are available in chronically implanted patients. Methods Sixteen patients with chronic atrial tachyarrhythmi and complete AV block were included. Left ventricular ejection fraction (LVEF) was ≥40% in ten and <40% in six. Patients were implanted with standard DDDR pacemaker connected to two ventricular leads. screw-in lead was placed at the RVOT and connected to the atrial port. second lead was positioned at the RV and connected to the ventricular port. Right ventricular outflow tract and RV pacing was achieved by programming either the AAIR or the VVIR mode respectively. Four months later patients were randomized so as to undergo either RVOT or RV pacing for three months according to blind crossover protocol. Apart from the pacing mode, programming remained unchanged throughout the study. At the end of each period, NYH class, LVEF, exercise time and maximal oxygen uptake were assessed. Results No significant difference was observed between the two modes for all the parameters analyzed. These identical results were observed in all patients globally, in patients with LVEF ≥40% as in those with LVEF <40%. Conclusions Within the limits of this study, no symptomatic improvement or hemodynamic benefit was noted after three months of RVOT pacing, by comparison with RV pacing.