Changes in antioxidant status of lung tissue in experimental diabetes in rabbits

Objectives: Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage. Design and methods: After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits. Results: Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung. Conclusions: The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications.