Author/Authors :
Jaemoon Yang، نويسنده , , Eun-Kyung Lim، نويسنده , , Hong Jae Lee، نويسنده , , Joseph Park، نويسنده , , Sang Cheon Lee، نويسنده , , Kwangyeol Lee، نويسنده , , Ho-Geun Yoon، نويسنده , , Jin-Suck Suh، نويسنده , , Yong-Min Huh، نويسنده , , Seungjoo Haam، نويسنده ,
Abstract :
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
Keywords :
fluorescence , cancer , cetuximab , Magnetic nanoparticle , Nanohybrid
