Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma

Objectives To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. Methods MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme. Results Significant differences in allele frequencies between groups were not ascertained. Conclusions Pursuant to these results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for bronchial asthma in the Czech population