Author/Authors :
Agostino Ognibene، نويسنده , , Edoardo Mannucci، نويسنده , , Anna Caldini، نويسنده , , Alessandro Terreni، نويسنده , , Marco Brogi، نويسنده , , Gianluca Bardini، نويسنده , , Iolanda Sposato، نويسنده , , Valentina Mosconi، نويسنده , , Benedetta Salvadori، نويسنده , , Carlo Maria Rotella، نويسنده , , Gianni Messeri، نويسنده ,
Abstract :
Objectives:
The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.
Design and methods:
The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.
Results:
CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (< 45 years, < 0.95 mg/L and > 45 years, < 1.20 mg/L).
Conclusions:
The use of CysC reference values adjusted for age should be carefully taken into consideration.
Keywords :
glomerular filtration rate , Creatinine , cystatin C , Reference value
