Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes

Objectives: To determine the minimally modified electronegative LDL (LDL−) and its autoantibodies in coronary syndromes. Design and methods: LDL(−) and its autoantibodies were determined by ELISA in patients with acute (ACS, unstable angina; AMI, acute myocardial infarction) and chronic coronary syndromes (stable angina, SA) and compared to subjects without coronary disease (controls). Results are expressed as median of LDL− (μg/mL) and anti-LDL(−) IgG (OD405 nm). Results: The concentrations of LDL(−) were higher in patients with coronary disease (ACS: 40.7 μg/mL; SA: 35.0 μg/mL) as compared to controls (21.6 μg/mL). The highest LDL− concentrations were found in patients with AMI (41.8 μg/mL). Anti-LDL(−) IgG was elevated in ACS (1.143) in relation to CCS (0.527) and controls (0.467). A positive correlation was observed between anti-LDL− IgG and CRP levels (r = 0.34, p < 0.01) in the studied groups. Conclusions: LDL(−) and anti-LDL(−) autoantibodies may be useful markers to follow patients with high risk for coronary events.