Hexosaminidase as a new potential marker for middle ear cholesteatoma

Objectives: The study aim was to investigate the activities of hexosaminidase (HEX) in cholesteatoma tissue compared with that in normal skin. Design and methods: The enzyme activities were determined using the Chatterjee et al. method in the modification of Zwierz et al. in cholesteatoma and skin. Results: Significantly higher activity of hexosaminidase was observed in cholesteatoma tissue compared with the skin. Conclusions: Hex may be considered as a new pathogenetic factor in that destructive lesion.