Title of article :
Mutual interference between serum thyroglobulin and antithyroglobulin antibody in an automated chemiluminescent immunoassay
Author/Authors :
Yunchao Gao، نويسنده , , Zhibin Yuan، نويسنده , , Yongli Yu، نويسنده , , Hankui Lu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Objectives:
To investigate the analytical interference between serum Tg and TgAb.
Design and methods:
Tg and TgAb were measured on an automated chemiluminescent immunoassay system in mixed sera from DTC patients and individual samples spiked with exogenous Tg.
Results:
Tg and TgAb recoveries in mixed patient samples were inversely correlated with expected TgAb or Tg concentrations, respectively. Impaired TgAb recoveries were also found in 50% (10/20) samples with high Tg in the exogenous recovery tests.
Conclusions:
Mutual but not equal analytical interference between Tg and TgAb is present and concentration-dependent with interpatient variability.
Keywords :
Analytical interference , Thyroglobulin , Antithyroglobulin antibody , Chemiluminescent immunoassay
Journal title :
Clinical Biochemistry
Journal title :
Clinical Biochemistry