Percentage non-caeruloplasmin bound copper

Objectives: To compare percentage non-caeruloplasmin bound copper (%NCC) to generally accepted values. Design and methods: Using data for 338 normal individual patients, we calculated the %NCC. Results: The %NCC ranged (median) from − 59.75% to 51.98% (8.75%) respectively. The non-parametric reference interval was − 23.44% to 22.99% with 43.8% of the %NCC values > 10%. Conclusions: We found the %NCC to be higher than generally accepted. This may be due to uncertainty from precision, bias and specificity.