Variability in apo(a) gene regulatory sequences, compound genotypes, and association with Lp(a) plasma levels

Objectives: Lipoprotein(a) is an independent risk factor of atherosclerosis. Design and methods: We assigned frequencies of six polymorphic sites from apo(a) gene transcription control regions, linkage disequilibrium, and 5-polymorphic compound genotypes association with Lp(a) levels. Results: Significant linkage disequilibrium between polymorphic sites was detected. Compound genotypes were significantly associated with Lp(a) levels (P < 0.0001). Major 5-polymorphic genotypes were distributed in a broad range of concentrations. Conclusions: Major 5-polymorphic compound genotypes are not associated with restricted range of Lp(a) levels.