Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population

Objectives: To investigate the association between matrix metalloproteinase (MMP)-1(− 1607 1G/2G), MMP-3(− 1171 5A/6A), and MMP-9(− 1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM). Design and methods: MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis. Results: Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls. Conclusions: Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM