Title of article
Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population
Author/Authors
Li-jiang Tang، نويسنده , , Xiaofeng Chen، نويسنده , , Min Zhu، نويسنده , , Jian-Jun Jiang، نويسنده , , Xian-ben Lu، نويسنده , , Yu-xi Du، نويسنده , , Bin Wang، نويسنده , , Chong-feng Fang، نويسنده , , Yin-sheng Xue، نويسنده , , Wei Feng Shen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1427
To page
1430
Abstract
Objectives:
To investigate the association between matrix metalloproteinase (MMP)-1(− 1607 1G/2G), MMP-3(− 1171 5A/6A), and MMP-9(− 1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM).
Design and methods:
MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis.
Results:
Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls.
Conclusions:
Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM
Keywords
restriction fragment length polymorphism (RFLP) , polymerasechain reaction (PCR) , Idiopathic dilated cardiomyopathy (IDCM) , Matrix metalloproteinase-1 , -3 , -3 , -9 (MMP-1 , -9) , Single nucleotide polymorphism (SNP)
Journal title
Clinical Biochemistry
Serial Year
2007
Journal title
Clinical Biochemistry
Record number
485095
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