Correlation between lipoprotein(a) serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score

Objectives To investigate the correlation between serum lipoprotein(a) concentration and existence as well as severity of coronary atherosclerosis. Design and methods A cross-sectional study was conducted on 826 patients who underwent angiography through measuring blood sugar, serum lipids, lipoprotein(a) and evaluation of coronary stenosis by Gensini score. Results Gensini score = 6 was considered as a cut-off point for coronary disease and 40 mg/dL was determined as lipoprotein(a) cut-off point. Its higher concentration was significantly more frequent in patients with Gensini score > 6 (OR: 2.50, p = 0.001), independent of gender, smoking, diabetes mellitus and hyperlipidemia. This finding was significant in patients < 55 years old. There was a significant relationship between severity of coronary stenosis and higher concentration of serum lipoprotein(a). Conclusion LP(a) serum concentration is an independent risk factor for coronary atherosclerosis in the Iranian population especially at the ages below 55. Also it demonstrates a direct relationship between severity of coronary atherosclerosis (by Gensini score) and serum LP(a).