Rapid electrochromatographic enantiomer separations on short molecularly imprinted polymer monoliths

Very rapid capillary electrochromatography (CEC) mode enantiomer separations of propranolol using short super-porous monolithic molecularly imprinted polymers (MIPs) were studied. MIP stationary phases were synthesised by an in situ photo-initiated polymerisation reaction. The effect of electrolyte composition on the enantiomer separation and the stability of the MIP-column performance was investigated. The optimised MIP¯CEC separation system was able to resolve the enantiomers of propranolol in less than 1 min.