Criterion for Hill equation validity for description of biosensor calibration curves

The applicability of well-known three-parameter Hill equation for description of calibration curves for potentiometric (detection of glucose, pesticides, urea) and amperometric (detection of surfactants, biphenyl, nitrite) biosensors has been analyzed. The criterion for validity of the Hill equation has been proposed. The sources of errors at the determination of concentration of the substance being analyzed have been considered.