Noisy spiking neurons and networks: useful approximations for firing probabilities and global behavior

Electrophysiological properties of spiking neurons receiving complex stimuli perturbed by noise are investigated. A semi-analytical estimate of firing probabilities and subthreshold behavior of the stochastic system can be made in terms of the solution of a purely deterministic system. The method comes from an approximation for the distribution function and moments of the underlying non linear multidimensional diffusion process. This so called moment method works for general conductance-based systems and an application is presented for the Hodgkin–Huxley neuronal model. Statistical properties obtained from the moment method are compared with direct numerical integration of the stochastic system. The firing probability due to external noise is derived as a closed formula. Results are given for different forms of the deterministic component of the stimulus. A generalization to neural networks of conductance-based systems with internal currents perturbed by noise can be obtained using the same approach. In the case of fully connected networks, a mean field population equation is derived which may be compared to Kuramoto’s master equation for weakly coupled neural oscillators.