Title of article :
Formation and maintenance of tubular membrane projections: Experiments and numerical calculations
Author/Authors :
Tamiki Umeda، نويسنده , , Takehiko Inaba، نويسنده , , Akihiko Ishijima، نويسنده , , Kingo Takiguchi، نويسنده , , Hirokazu Hotani، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
115
To page :
119
Abstract :
To study the mechanical properties of lipid membranes, we manipulated liposomes by using a system comprising polystyrene beads and laser tweezers, and measured the force required to transform their shapes. When two beads pushed the membrane from inside, spherical liposomes transformed into a lemon-shape. Then a discontinuous shape transformation occurred to form a membrane tube from either end of the liposomes, and the force dropped drastically. We analyzed these processes using a mathematical model based on the bending elasticity of the membranes. Numerical calculations showed that when the bead size was taken into account, the model reproduced both the liposomal shape transformation and the force–extension relation. This result suggests that the size of the beads is responsible for the existence of a force barrier for the tube formation.
Keywords :
Membrane tube , simulation , vesicle , Liposome , Bending elasticity , Laser tweezer
Journal title :
BioSystems
Serial Year :
2008
Journal title :
BioSystems
Record number :
498030
Link To Document :
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