The genes encoding the 5HT1Dα and 5HT1Dβ receptors are unchanged in patients with panic disorder

To determine the serotonergic function in panic disorder, sequencing of the genes encoding the 5HT1Dα and 5HT1Dβ receptors was carried out. The genes for the 5HT1Dα and 5HT1Dβ receptors were amplified by polymerase chain reaction and sequenced by the dideoxy method. Some patients have both nucleotides C and T at position 1080 in 5HT1Dα receptor gene; however, both of them code the same amino acid, asparagine. The 5HT1Dβ receptor gene had a substitution from GCA276 to GCG276, not only panic disorder but also in controls; however, this substitution does not change the corresponding amino acid, alanine92.