Author/Authors :
Frederick Petty، نويسنده , , A. John Rush، نويسنده , , John M. Davis، نويسنده , , Joseph R. Calabrese، نويسنده , , Susan E. Kimmel، نويسنده , , Gerald L. Kramer، نويسنده , , Joyce G. Small، نويسنده , , Marvin J. Miller، نويسنده , , Alan E. Swann، نويسنده , , Paul J. Orsulak، نويسنده , , Molly E. Blake، نويسنده , , Charles L. Bowden، نويسنده ,
Abstract :
Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p< .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.
Keywords :
bipolar disorder , GABA , Mania , Divalproex , lithium , Valproic acid , responseprediction
