• Title of article

    CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

  • Author/Authors

    Alastair G. Cardno، نويسنده , , Timothy Bowen، نويسنده , , Carol A. Guy، نويسنده , , Lisa A. Jones، نويسنده , , Geraldine McCarthy، نويسنده , , Nigel M. Williams، نويسنده , , Kieran C. Murphy، نويسنده , , Gillian Spurlock، نويسنده , , Marion Gray، نويسنده , , Robert D. Sanders، نويسنده , , Nick Craddock، نويسنده , , Peter McGuffin، نويسنده , , Michael J. Owen، نويسنده , , Michael C. O’Donovan، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1999
  • Pages
    5
  • From page
    1592
  • To page
    1596
  • Abstract
    Background: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. Methods: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. Results: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. Conclusions: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.
  • Keywords
    Schizophrenia , Trinucleotide repeats , association , negative symptoms , Potassium channel
  • Journal title
    Biological Psychiatry
  • Serial Year
    1999
  • Journal title
    Biological Psychiatry
  • Record number

    500914

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=500914