Effectiveness of chromium in atypical depression: a placebo-controlled trial

Background Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression. Methods A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 μg of CP or matching placebo (PBO) for 8 weeks. Results Seven (70%) CP and zero (0%) PBO patients met responder criteria (p = .02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated. Conclusions Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.