The killer and the executioner: how apoptosis controls malignancy

An escalating research effort focused on apoptotic cell death continues to chip away at the central mechanisms of this intriguing process. One of the areas in which this research has already yielded fundamental insights is in the analysis of oncogenesis, where defects in cell death can have profound effects. Recent progress has been made in understanding the processes of apoptosis induction, transduction, and effect (or ‘execution’), especially with respect to our understanding of malignancy, hyperplasia and related phenomena.