Thiamin deficiency in HIV-positive patients: evaluation by erythrocyte transketolase activity and thiamin pyrophosphate effect

Background and aims: The aim of the study was to determine the thiamin status in HIV-positivepatients. Methods: Measurement of erythrocyte transketolase activity (ETK) and thiaminpyrophosphate (TPP)effect in 55 consecutive HIV-positive patients of a specialized outpatient clinic were grouped into five groups according to their CD4 counts. Comparison of results of HIV-positive patients with age-matched control group of 22 healthy subjects. Results: Of the patients, 27% had a pathologically-increased TPP effect, 18% of the patients had pathologically-low ETK. The percentage of pathological values of TPP effect in the patients was significantly higher compared with the control group. There was no statistically significant correlation between pathological thiamin status and stage of the disease, zidovudine therapy or nutritional status of the patients. Conclusions: Thiamin deficiency in HIV-positive patients was found in a higher percentage than previouslyreported. Thiamine deficiency is not only present in advanced stages of HIV-infection, but also in clinically asymptomatic patients.