Title of article :
Effect of Lactobacillus gasseri PA 16/8,
Bifidobacterium longum SP 07/3, B. bifidum MF
20/5 on common cold episodes: A double blind,
randomized, controlled trial
Author/Authors :
Michael de Vrese ، نويسنده , , Petra Winkler، نويسنده , , Peter Rautenberg، نويسنده , , Timm Harder، نويسنده , ,
Christian Noah، نويسنده , , Christiane Laue، نويسنده , , Stephan Ott، نويسنده , , Jochen Hampe، نويسنده , , Stefan Schreiber، نويسنده , , Knut Heller، نويسنده , , Jurgen Schrezenmeir، نويسنده ,
Abstract :
Background & aims: The aim of this study was to investigate whether the
consumption of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3,
B. bifidum MF 20/5 (5 107 cfu/tablet) during at least 3 months influences the
severity of symptoms and the incidence and duration of the common cold.
Methods: A randomized, double-blind, placebo-controlled intervention study
was performed over at least 3 months during two winter/spring periods. Four
hundred and seventy nine healthy adults (aged 18–67) were supplemented daily with
vitamins and minerals with or without the probiotic bacteria. Cellular immune
parameters were evaluated in a randomly drawn subgroup of 122 volunteers before
and after 14 days of supplementation. During common cold episodes, the
participants recorded symptoms daily. Stool samples were collected before and
after 14 days of probiotic supplementation to quantify fecal Lactobacilli and
Bifidobacteria using qRT-PCR.
Keywords :
Common Cold , Respiratory tractinfections , Immune system , Probiotics
