Author/Authors :
Mariette A Oosterwegel، نويسنده , , Rebecca J Greenwald، نويسنده , , Didier A Mandelbrot، نويسنده , , Robert B Lorsbach، نويسنده , , Arlene H Sharpe، نويسنده ,
Abstract :
The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1 /Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.
