Title of article
CTLA-4 and T cell activation
Author/Authors
Mariette A Oosterwegel، نويسنده , , Rebecca J Greenwald، نويسنده , , Didier A Mandelbrot، نويسنده , , Robert B Lorsbach، نويسنده , , Arlene H Sharpe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
7
From page
294
To page
300
Abstract
The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1 /Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.
Journal title
Current Opinion in Immunology
Serial Year
1999
Journal title
Current Opinion in Immunology
Record number
511843
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