Biological effects of induction immunosuppression

The concept of induction immunosuppression is evolving. Once used to buttress the inadequacies of past maintenance immunosuppressive regimens, it is now being used to permit effective maintenance immunosuppression using ever decreasing amounts of modern agents. In addition to lymphocyte depletion, with which it was once synonymous, it is now recognized that induction immunosuppression is associated with a host of non-depletional effects such as receptor modulation and blockade, which profoundly alter the lymphocyte’s capacity to mount an effective response. Additionally, the recent focus on the effect of induction agents on antigen presenting cells and on regulatory factors controlling homeostatic repopulation may ultimately permit a safer, more refined and more effective approach to induction immunosuppression.