Title of article :
Gene regulatory networks and the determination of lymphoid cell fates
Author/Authors :
Harinder Singh، نويسنده , , Jagan MR Pongubala، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
116
To page :
120
Abstract :
Considerable progress has been achieved in the identification and analysis of regulatory molecules that orchestrate B and T cell fate determination. IL-7 and Notch signaling appear to represent analogous pathways that direct B and T cell fates, respectively. For the B lineage, it is possible to assemble the various signaling components and transcription factors into a coherent gene regulatory network. At present, it is not possible to assemble an equivalently precise network for the T lineage as fewer components have been analyzed and their connectivity remains to be more fully explored. However, the ability to manipulate T cell development in a simple culture system using Notch ligand-expressing stromal cells is greatly facilitating analysis of this pathway.
Journal title :
Current Opinion in Immunology
Serial Year :
2006
Journal title :
Current Opinion in Immunology
Record number :
512630
Link To Document :
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