Early patterning of the mouse embryo: Implications for hematopoietic commitment and differentiation

Prior to and during gastrulation, reciprocal interactions between embryonic and extraembryonic lineages are crucial for the correct patterning of the embryo. Several lines of investigation have underscored the importance of extraembryonic ectoderm and primitive endodermal in establishing the anterior-posterior axis of the embryo. Signals from these tissues help to position the primitive streak, from which mesoderm will emerge, within the epiblast (embryo proper). Molecules secreted by the visceral endoderm are required for activation of hematopoietic and endothelial cell development, but the pathways involved and their target tissue (e.g., posterior epiblast versus extraembryonic mesoderm) remain obscure. Recent evidence suggests that commitment of mesodermal progenitors to the hematopoietic and endothelial lineages begins earlier than previously anticipated, within or shortly after these cells emerge from the primitive streak.