Title of article
Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts
Author/Authors
Jeremy P. E. Spencer، نويسنده , , Hagen Schroeter، نويسنده , , Andrew J. Crossthwaithe، نويسنده , , Gunter Kuhnle، نويسنده , , Robert J. Williams، نويسنده , , Catherine Rice-Evans، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
1139
To page
1146
Abstract
The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.
Keywords
Epicatechin glucuronide , Flavonoid , 3?-O-methyl epicatechin , Uptake , oxidative stress , bioactivity , Neuron , free radicals , fibroblast
Journal title
Free Radical Biology and Medicine
Serial Year
2001
Journal title
Free Radical Biology and Medicine
Record number
518984
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