Title of article :
Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases
Author/Authors :
Roman Ginnan، نويسنده , , Benjamin J. Guikema، نويسنده , , Katharine E. Halligan، نويسنده , , Harold A. Singer، نويسنده , , David Jourdʹheuil، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
14
From page :
1232
To page :
1245
Abstract :
Inflammation plays a critical role in promoting smooth muscle migration and proliferation during vascular diseases such as postangioplasty restenosis and atherosclerosis. Another common feature of many vascular diseases is the contribution of reactive oxygen (ROS) and reactive nitrogen (RNS) species to vascular injury. Primary sources of ROS and RNS in smooth muscle are several isoforms of NADPH oxidase (Nox) and the cytokine-regulated inducible nitric oxide (NO) synthase (iNOS). One important example of the interaction between NO and ROS is the reaction of NO with superoxide to yield peroxynitrite, which may contribute to the pathogenesis of hypertension. In this review, we discuss the literature that supports an alternate possibility: Nox-derived ROS modulate NO bioavailability by altering the expression of iNOS. We highlight data showing coexpression of iNOS and Nox in vascular smooth muscle demonstrating the functional consequences of iNOS and Nox during vascular injury. We describe the relevant literature demonstrating that the mitogen-activated protein kinases are important modulators of proinflammatory cytokine-dependent expression of iNOS. A central hypothesis discussed is that ROS-dependent regulation of the serine/threonine kinase protein kinase Cδ is essential to understanding how Nox may regulate signaling pathways leading to iNOS expression. Overall, the integration of nonphagocytic NADPH oxidase with cytokine signaling in general and in vascular smooth muscle in particular is poorly understood and merits further investigation.
Keywords :
Smooth muscle , nitric oxide , INOS , Superoxide , NADPH oxidase , NF-?B , protein kinase C , MAP kinase , free radicals
Journal title :
Free Radical Biology and Medicine
Serial Year :
2008
Journal title :
Free Radical Biology and Medicine
Record number :
521267
Link To Document :
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