Spacer arm influence on glucidoamphiphile compound properties

We prepared glucidoamphiphile derivatives from D-glucose, D-galactose and xylitol, in which the glucidic moiety and the hydrophobic alkyl chain are separated by spacer arm E (E=glyceryl, (OEt)2-alpha-polypropyleneglycyl and butyloxy). Their amphiphile characteristics are compared to those of the corresponding analogs 3-O-alkyl-D-glucopyranoses, 6-O-alkylD-galactopyranoses and 1-O-alkyl-D,L-xylitols. We discussed the spacer arm influence on hydrophobic lipophilic balance (HLB), critical micellar concentration (CMC), water solubility (Sw) and phase transition temperatures of thermotropic and lyotropic mesophases.