Differences between the N1 waves of the responses to interaural time and intensity disparities: scalp topography and dipole sources

Objectives: Being the two complementary cues to directional hearing, interaural time and intensity disparities (ITD and IID, respectively), are known to be separately encoded in the brain stem. We address the question as to whether their codes are collapsed into a single lateralization code subcortically or they reach the cortex via separate channels and are processed there in different areas. Methods: Two continuous trains of 100/s clicks were dichotically presented. At 2 s intervals either an interaural time delay of 1ms or an interaural level difference of 20 dB (HL) was introduced for 50 ms, shifting the intracranial sound image laterally for this brief period of time. Long-latency responses to these directional stimuli, which had been tested to evoke no potentials under monotic or diotic conditions, as well as to sound pips of 50 ms duration were recorded from 124 scalp electrodes. Scalp potential and current density maps at N1 latency were obtained from thirteen normal subjects. A 4-sphere head model with bilaterally symmetrical dipoles was used for source analysis and a simplex algorithm preceded by a genetic algorithm was employed for solving the inverse problem. Results: Inter- and intra-subject comparisons showed that the N1 responses evoked by IID and ITD as well as by sound pip stimuli had significantly different scalp topographies and interhemispheric dominance patterns. Significant location and orientation differences between their estimated dipole sources were also noted. Conclusion: We conclude that interaural time and intensity disparities (thus the lateral shifts of a sound image caused by these two cues) are processed in different ways and/or in different areas in auditory cortex.