Author/Authors :
Yamada، Y. نويسنده , , Ikeda، T. نويسنده , , Nakade، T. نويسنده , , Yokota، H. نويسنده , , Taniyama، H. نويسنده , , Hori، Y. نويسنده , , Agata، N. نويسنده , , Furusaki، H. نويسنده , , Uchida، Y. نويسنده , , Yuasa، A. نويسنده , , Yamaguchi، M. نويسنده , , Otomo، K. نويسنده ,
Abstract :
Chitin was found to induce matrix metalloproteinases (MMPs) activity in rat skin and subcutaneous tissue. Sponge type chitin (22.5 mg) was implanted in subcutaneous tissue of 8-week-old rats by skin incision. MMPs activity was more pronounced in the chitin-treated group than only incision group until on day 2.5 postoperatively. Gelatin zymography revealed that the induced MMPs had a molecular mass of 92 and 82 kDa corresponding to MMP-9 and pro MMP-9, respectively. We here discuss the mechanism of MMP induction by chitin.
Keywords :
Molecular weight (Mw) , Structure , Wheat beta-D-glucan , NMR spectroscopy
