Title of article :
Effect of spinal transcutaneous direct current stimulation on somatosensory evoked potentials in humans
Author/Authors :
Filippo Cogiamanian، نويسنده , , Maurizio Vergari، نويسنده , , Francesca Pulecchi، نويسنده , , Sara Marceglia، نويسنده , , Alberto Priori، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
2636
To page :
2640
Abstract :
Objective Invasive stimulation of the spinal cord is used to treat a number of pathological conditions. Aiming to modulate human spinal cord function non-invasively, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in conduction along the sensory spinal pathways. Methods Somatosensory evoked potentials (SEPs) by posterior tibial nerve and by median nerve stimulation were recorded, before, at current offset and at 20 min after transcutaneous anodal or cathodal DC stimulation over the thoracic spinal cord (2.5 mA, 15 min) in a group of 12 healthy subjects. Results Whereas both polarities left the spinal (N22) and the cortical potentials (P39) unchanged, anodal transcutaneous spinal DC stimulation decreased significantly by about 25% the amplitude of the cervico-medullary component of posterior tibial nerve SEPs (P30) for at least 20 min. Thoracic transcutaneous spinal cord stimulation left median nerve SEPs unchanged. Conclusions Transcutaneous DC stimulation over the thoracic spinal cord induces changes in conduction along human lemniscal pathway that persist after stimulation ends. Significance Our results support the use of transcutaneous DC stimulation as a novel tool for non-invasive spinal neuromodulation. Because the method is non-expensive and simple, it can be tested in patients with disorders presently treated with invasive procedures.
Keywords :
Direct current stimulationSpinal cordSEPsSpinal cord stimulation
Journal title :
Clinical Neurophysiology
Serial Year :
2008
Journal title :
Clinical Neurophysiology
Record number :
524905
Link To Document :
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