Title of article :
Exclusion of KCNE1 (IsK) as a Candidate Gene for Jervell and Lange-Nielsen Syndrome
Author/Authors :
Frédérique Tesson، نويسنده , , Claire Donger، نويسنده , , Isabelle Denjoy، نويسنده , , Myriam Berthet، نويسنده , , Mohammed Bennaceur، نويسنده , , Christine Petit، نويسنده , , Philippe Coumel، نويسنده , , Ketty Schwartz، نويسنده , , Pascale Guicheney، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
5
From page :
2051
To page :
2055
Abstract :
The KCNE1 gene encodes a small protein, IsK, of 14.4 kDa, with a single transmembrane domain, and is part of a potassium channel expressed in the heart. This channel is thought to underly the very slow component of the cardiac delayed rectifying current which controls the duration and the degree of ventricular repolarization. This suggested that KCNE1 could be the morbid gene responsible for an autosomal recessive cardio-auditory disease, the Jervell and Lange-Nielsen syndrome, characterized by ventricular repolarization abnormalities and recurrent syncopes leading eventually to sudden death associated with a bilateral congenital deafness. By linkage analysis in four consanguinous families, using microsatellite markers of chromosome 21 as well as KCNE1 intragenic polymorphisms, we excluded KCNE1 as a candidate gene for Jervell and Lange-Nielsen syndrome. In addition, we described a new polymorphism, a G-to-A substitution at position 253, in the KCNE1 coding sequence detectable by SSCP analysis or RFLP.
Keywords :
Jervell and Lange-Nielsen syndrome , Potassium channel , KCNE1 , IsK , RFLP , long QT syndrome
Journal title :
Journal of Molecular and Cellular Cardiology
Serial Year :
1996
Journal title :
Journal of Molecular and Cellular Cardiology
Record number :
525530
Link To Document :
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