Title of article
Effect of pH on the production of the antitumor antibiotic retamycin by Streptomyces olindensis
Author/Authors
Guimaraes، Luciana M. نويسنده , , Furlan، Renata L. de Araujo نويسنده , , Garrido، Leandro M. نويسنده , , Ventura، Armando نويسنده , , Padilla، Gabriel نويسنده , , Facciotti، Maria Candida R. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
-106
From page
107
To page
0
Abstract
The effect of pH on cell growth and retamycin production in batch bioreactor cultures of Streptomyces olindensis ICB20 was investigated. In fermentations pH-controlled over the range 6.0–8.0, the highest retamycin production was achieved at pH 7.0, and the maximum concentration of retamycin, about 1.36 A (absorbance) units, was about 43, 58 and 232% higher than the values obtained at pH 7.5, 6.0 and 8.0 respectively.
Keywords
Streptomyces. , antitumour , antibiotics , retamycin , anthracyclines , pH
Journal title
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Serial Year
2004
Journal title
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Record number
52577
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