Emergency Identification and Treatment of Acute Ischemic Stroke Review Article

In this review we describe the pathophysiology of cerebral ischemia and its implications for potential therapy. We summarize the results of recently completed trials of acute stroke intervention and explore some of the controversy surrounding thrombolysis for acute stroke. We also introduce the key concepts of neuroprotection and its therapeutic possibilities. Finally, we discuss the delays that may occur in the emergency evaluation and management of acute ischemic stroke and suggest some methods to expedite the process. [Kasner SE, Grotta JC: Emergency identification and treatment of acute ischemic stroke. Ann Emerg Med November 1997;30:642-653.]