Treatment of Methanol Poisoning With Intravenous 4-Methylpyrazole, , ,

Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery. [Burns MJ, Graudins A, Aaron CK, McMartin K, Brent J: Treatment of methanol poisoning with intravenous 4-methylpyrazole. Ann Emerg Med December 1997;30:829-832.]