Author/Authors :
John R. Finch، نويسنده , , William R. Banks، نويسنده , , Dah-Ren Hwang، نويسنده , , Martin R. Satter، نويسنده , , Bilal Ezzidene، نويسنده , , Joseph C. Mantil، نويسنده , , George A. Digenis، نويسنده ,
Abstract :
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99 + % radiochemically pure [18F]HFA-134a in 20–35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the me an half-life of [18F]HFA-134a in four rats was determined to be 7.8 ± 1.5 min following a 10 s exposure and 8.1 ± 1.7 minutes following a 10 min exposure.
