The synthesis of 191Pt labelled JM216, an orally active platinum anti-tumour agent

The orally active platinum anti-tumour complex JM216 [bis-acetatoamminedichlorocyclohexylamineplatinum(IV)] is at present in stage II clinical trials. A procedure for synthesising the complex labelled with 191Pt or 188Pt at the platinum centre has been developed. The purity (shown by HPLC) is 98% and the specific activity (0.3–0.4 Ci/kg) is enough for in vivo and in vitro studies.