[13N]Cisplatin: a fast and efficient on-line synthesis using a solid state support

A new, convenient and fast on-column method using a strong anion exchange resin as the solid state support has been developed for the on-line synthesis of nitrogen-13 (T1/2 = 9.96 min) labelled cisplatin ([13N]cisplatin). The whole synthesis, including sterile formulation of the product, is accomplished within 15 min. Using this method, after optimization of the reaction parameters, carrier-added [13N]cisplatin (1) can be obtained ready for injection in a decay-corrected radiochemical yield of 80% with a specific radioactivity of 30 MBq/μmol and a radiochemical purity of >98%.