Title of article
Regiospecific synthesis of 15-(4-[123I]iodophenyl)pentadecanoic acid-IPPA via methyl 15-(4-trimethylstannylphenyl)pentadecanoate
Author/Authors
Paul A. Culbert، نويسنده , , Jianming Lu، نويسنده , , Michael J. Adam، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
3
From page
745
To page
747
Abstract
The synthesis of methyl 15-(4-trimethylstannylphenyl)pentadecanoate (p-SnPPA), a precursor for the regiospecific production of 15-(4-[123I]-iodophenyl)pentadecanoic acid, is described. The stannylated precursor is synthesized in six steps from 4-bromophenylacetylene in an overall yield of 16%. p-SnPPA reacts with N.C.A. [123I]NaI in the presence of peracetic acid to yield IPPA in 62% radiochemical yield following hydrolysis.
Journal title
Applied Radiation and Isotopes
Serial Year
1997
Journal title
Applied Radiation and Isotopes
Record number
539824
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