Title of article
4-[18F]fluoromethylbenzylsulfonate ester: a rapid and efficient synthetic method for the N-[18F]fluoromethylbenzylation of amides and amines
Author/Authors
Yearn Seong Choe، نويسنده , , Dong Hyuck Song، نويسنده , , Kee-Jung Lee، نويسنده , , Sang-Eun Kim، نويسنده , , Yong Choi، نويسنده , , Kyung-Han Lee، نويسنده , , Byung-Tae Kim، نويسنده , , Seung-Jun Oh، نويسنده , , Dae Yoon Chi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
5
From page
73
To page
77
Abstract
We have prepared 4-[18F]fluoromethylbenzylsulfonate esters as fluoromethylbenzylating agents. These agents are readily prepared by an [18F]fluoride ion displacement of the corresponding bissulfonate esters. The application of these 4-[18F]fluoromethylbenzylsulfonate esters to N-alkylation reaction of spiperone and 1-phenylpiperazine shows that the products 3-N-(4-[18F]fluoromethylbenzyl)spiperone and 1-N-(4-[18F]fluoromethylbenzyl)-4-phenylpiperazine are rapidly produced with high radiochemical yields under a no-carrier-added condition.
Journal title
Applied Radiation and Isotopes
Serial Year
1998
Journal title
Applied Radiation and Isotopes
Record number
539979
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