Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β(4′ methylphenyl) nortropane (FPCMT)

A synthetic procedure for the routine preparation of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4′ methylphenyl) nortropane (18F FPCMT) has been developed. The synthesis is based on alkylation of nortropane with 18F labeled fluoropropyl tosylate. Purification of the final product was achieved by a preparative HPLC procedure using Alltech Econosil column. Separation of the desired compound was achieved and the product was clean. The radiochemical yield (without decay correction) is 4 to 5%, calculated at the end of the synthesis based on the total amount of fluorine recovered from the target. Radiochemical purity was in the range of 98 to 99%.