Experimental determinations of commercial ‘dose calibrator’ settings for nuclides used in nuclear medicine

Commercial reentrant ionization chambers (‘dose calibrators’) have become the de facto standard instrument for making radioactivity measurements in the radiopharmaceutical industry. Accurate activity measurements, however, depend on the application of the correct calibration factor (dial setting) for the radionuclide in the exact measurement geometry for that particular instrument. Two methods are described for the experimental determination of dial settings for the Capintec CRC-12 dose calibrator. Using these methods, we have determined new calibration factors for 18F, 62Cu, 186Re and 188Re in several geometries. These new factors are presented, along with previously determined settings, for nuclides commonly used in nuclear medicine. The differences between the calibration factors for the different geometries, as well as the differences between the manufacturerʹs recommended setting underscore the need for empirically determined dose calibrator settings.