Title of article
Labelling of Re-ABP with 188Re for bone pain palliation
Author/Authors
Consuelo Arteaga de Murphy، نويسنده , , Guillermina Ferro-Flores، نويسنده , , Martha Pedraza-L?pez، نويسنده , , Laura Meléndez-Alafort، نويسنده , , Barbara Y. Croft، نويسنده , , Flor de Mar?a Ram?rez، نويسنده , , Juan Padilla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
435
To page
442
Abstract
Etidronate and medronate have been labelled with technetium-99m (99mTc-HEDP, 99mTc-MDP) for bone scanning and, with rhenium-188 (188Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-188Re. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [188Re]Re-ABP and similarities with 99mTc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation.
Keywords
188Re-ABP , 188Re-Alendronate , 188Re labelled bisphosphonates
Journal title
Applied Radiation and Isotopes
Serial Year
2001
Journal title
Applied Radiation and Isotopes
Record number
540922
Link To Document