Title of article
Automated synthesis of 16α-[18F]fluoroestradiol-3,17β-disulphamate
Author/Authors
Johannes R?mer، نويسنده , , Frank Füchtner، نويسنده , , J?rg Steinbach، نويسنده , , Helmut Kasch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
9
From page
631
To page
639
Abstract
After 16α-[18F]fluoroestradiol ([18F]FES) has been successfully prepared in an automated module, the synthesis of 16α-[18F]fluoroestradiol-3,17β-disulphamate ([18F]FESDS) is described as a module-assisted one-pot procedure which can provide 10 GBq [18F]FESDS with a radiochemical purity better than 99%. The procedure is reliable and reproducible and requires a time of about 90 min. Because of its high sulphatase-inhibitory effect [18F]FESDS is thought to be a new PET tracer to image sites of high sulphatase activity.
Keywords
Nucleophilic fluorination , Sulphamoylation , Fluorine-18 , Steroidal sulphatase inhibitors , PET tracer , Automated synthesis
Journal title
Applied Radiation and Isotopes
Serial Year
2001
Journal title
Applied Radiation and Isotopes
Record number
541078
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