Title of article
An improved method for the preparation of [11C]verapamil
Author/Authors
T. D. Wegman، نويسنده , , B. Maas، نويسنده , , P. H. Elsinga، نويسنده , , W. Vaalburg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
505
To page
507
Abstract
This paper describes an improved preparation of [11C]verapamil by reaction of [11C]methyl triflate with desmethylverapamil. The optimal reaction temperature, amount of precursor and reaction time were assessed. With this method [11C]verapamil can be prepared with a reproducible radiochemical yield of 66±4% (EOB, based on [11C]methyltriflate). Total synthesis time was 60 min. Radiochemical purity was >99% and specific activities varied between 5 and 30 TBq/mmol.
Keywords
P-glycoprotein , Multidrug resistance (MDR) , positron emission tomography
Journal title
Applied Radiation and Isotopes
Serial Year
2002
Journal title
Applied Radiation and Isotopes
Record number
541332
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